Endotoxaemia in Obstructive Jaundice

Endotoxaemia in Obstructive Jaundice

Surgical procedures in patients with obstructive jaundice are associated with significant morbidity and mortality1. This is due, to a large extent, to the development of postoperative complications such as sepsis, bleeding disorders and renal failure24. Clinical and experimental studies have suggested several aetiological factors for these complications including hypotension, impaired nutrition...

Endotoxaemia and renal failure in cirrhosis and obstructive jaundice.

An investigation into the possible role of endotoxins in the pathogenesis of renal failure in cirrhosis and obstructive jaundice showed the two to be closely related. None of the patients with cirrhosis who had endotoxaemia had other evidence of Gram-negative infection at the time of the study, and the endotoxaemia was therefore probably due to impaired hepatic clearance of toxins normally abso...

The Role of Endotoxaemia in the development of Renal Disorders Experimental Obstructive Jaundice in Rats

In rats with 2-week obstructive jaundice the sensitivity to endotoxin was studied and the effect of a single dose of endotoxin on histological development in the kidney, liver and spleen was also investigated. We were tested the effect on accumulation and distribution within organs, of fibrinogen labelled with radioactive iodine I 125. We showed an increased sensitivity to endotoxin in obstruct...

Prevention of Endotoxaemia in Obstructive Jaundice — a Comparative Study of Bile Salts

Systemic endotoxaemia is associated with postoperative renal dysfunction in obstructive jaundice, and can be prevented by the pre-operative administration of certain bile salts. In order to find the most effective bile salt for use in this condition, a comparison of the anti-endotoxic activities of different bile salts was performed. Bile salts were incubated in vitro with endotoxin and the res...

Obstructive Jaundice